Shazier will miss his second straight game
Roethlisberger was carted off and didn't return to the game.
Shazier had 15 tackles and a sack against the 49ers.
The Pittsburgh Steelers are already without their starting center, and the New England Patriots might not have their starting center Thursday night either.
Late last month, there was a report that the Steelers expected center Maurkice Pouncey to miss the first 10 games of the season with
Suisham has a torn anterior cruciate ligament and cartilage damage
Kicker Shaun Suisham Suffered a Knee Injury, Reportedly on the Third-quarter Kickoff